Must not have any major Mendelian disorders. Mendelian disorders fall into the following categories:
Autosomal dominant or X linked disorders
Autosomal dominant with reduced penetrance
Autosomal recessive (homozygous)
Must not have had any major malformations of complex cause, such as spina bifida or heart malformation. Major malformation is defined as one that carries serious functional or cosmetic significance.
Must not have any significant familial disease with a major genetic component. This limitation applies especially to first-degree relatives (i.e., parents, siblings, or offspring).
Should not carry a known karyotypic abnormality that may result in chromosomally unbalanced gametes. Karyotypic screening of the donor is optional and performed on request. Among healthy young adults, the chance of having a chromosomal rearrangement that could be transmitted in an unbalanced form to one's offspring is small.
Must not be a member of a high-risk group for Cystic Fibrosis.
The donor's first-degree relatives should be free of the following:
Mendelian disorders as described above.
Major malformations as described above.
Chromosomal abnormalities, unless the donor has a normal karyotype.
If family history reveals a disorder for which definitive screening is available and it is important to further consider that candidate as a donor, then it is appropriate to screen for selective disorders.
This protocol is in accordance with the recommendations of ASRM. as approved by the Board of Directors of the American Society for Reproductive Medicine, June 1997.
